Key result
cGMP analogues reduced force of contraction in cardiac muscle from wild-type mice but not from cGKI-null mutants, demonstrating that cGKI mediates the negative inotropic effect of cGMP.
cGMP-dependent protein kinase I (cGKI) is required to mediate the negative inotropic effect of cGMP in the murine myocardium.
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Findings in mice warrant no clinical change; extends cGKI role in cGMP signaling but leaves human relevance open.
Wegener et al. (2002) studied Cardiac contractility. cGMP analogues (8-Br-cGMP and 8-pCPT-cGMP) vs. cGKI-null mutants was evaluated on Force of contraction (F(c)). cGMP analogues reduced force of contraction in cardiac muscle from wild-type mice but not from cGKI-null mutants, demonstrating that cGKI mediates the negative inotropic effect of cGMP.
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