Key result
Twelve weeks of leg resistance training in healthy older men significantly increased plasma nitric oxide concentration from 39.6 to 61.2 µmol/l without increasing central arterial stiffness.
Why the study?
Does 12 weeks of leg resistance training improve arterial stiffness and endothelial function in healthy older men?
Does 12 weeks of leg resistance training improve arterial stiffness and endothelial function in healthy older men?
Absolute Event Rate: 61.2% vs 39.6%
p-value: p=<0.05
Short-term leg resistance training in healthy older men increases nitric oxide production without adversely affecting central arterial stiffness.
May support endothelial benefits from leg resistance training in older men without stiffness risk; hypothesis-generating and needs RCTs before practice change.
BACKGROUND: Little information is available on the effect of strength training on vascular function, particularly in older people. OBJECTIVE: To determine the effect of resistance training on arterial stiffness and endothelial function in older adults. METHOD: Eleven healthy men (mean (SEM) age 64 (1) years) performed 12 weeks of resistance training involving knee flexion and extension (three sets a day, two days a week). RESULTS: Resistance training increased maximal muscle power by 16% (p<0.0001). Arterial stiffness as assessed by aortic pulse wave velocity did not change with resistance training. Plasma concentration of nitric oxide (NO), measured as its stable end product (nitrite/nitrate), had increased (p<0.05) after resistance training (61.2 (10.4) v 39.6 (3.2) micromol/l). There was no change in plasma concentration of endothelin-1. CONCLUSION: The results suggest that short term resistance training may increase NO production without stiffening central arteries in healthy older men.
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Maeda et al. (2006) studied Healthy older men (n=11). Leg resistance training vs. Baseline (before training) was evaluated on Plasma nitrite/nitrate (NOx) concentration (µmol/l) (p=<0.05). Twelve weeks of leg resistance training in healthy older men significantly increased plasma nitric oxide concentration from 39.6 to 61.2 µmol/l without increasing central arterial stiffness.
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