Long-term muscle disuse causes preferential loss of the giant protein titin and abnormal sarcomeric organization, leading to depressed muscle performance.
No takes yet. Share an insight, caveat, or question.
Prolonged immobilization may impair muscle performance; leaves open whether titin loss drives human disuse atrophy.
Udaka et al. (2007) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: