Why the study?
Does long-term disuse reduce contractility and fatigue resistance in rat soleus muscle fibers?
Does long-term disuse reduce contractility and fatigue resistance in rat soleus muscle fibers?
Long-term disuse depresses contractile performance and reduces fatigue resistance in rat soleus muscle fibers due to lowered myofibrillar force-generating capacity and enhanced Pi inhibition linked to lattice spacing expansion.
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May inform mechanisms of disuse weakness in animal models; leaves open human translation and clinical relevance.
Udaka et al. (2011) studied this question.
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