Key result
Higher cardiometabolic index linked to increased all-cause and CV mortality in young adults with diabetes.
Why the study?
Given the rising incidence of type 2 diabetes mellitus among young adults, the relationship between the cardiometabolic index and mortality risk in early-onset diabetes remained to be determined.
Does a higher cardiometabolic index increase the risk of all-cause and cardiovascular mortality in young adults with type 2 diabetes mellitus?
Cohort (n=2,188)
Yes
Does a higher cardiometabolic index increase the risk of all-cause and cardiovascular mortality in young adults with type 2 diabetes mellitus?
Answers are grounded in this paper and cite their sources.
Higher cardiometabolic index is linearly associated with increased all-cause and cardiovascular mortality in young adults with diabetes, serving as a potential prognostic indicator.
Background The cardiometabolic index (CMI) has been utilized in recent years to detect patients with type 2 diabetes mellitus (T2DM). Given the consistent annual rise in the incidence of T2DM among young adults, the relationship between CMI and mortality risk among those with early-onset T2DM remains to be determined. Methods We enrolled 2,188 participants aged 20–65 with diabetes from the National Health and Nutrition Examination Survey (NHANES) 1999–2018. Weighted Cox proportional hazard regression models were employed to evaluate hazard ratios (HRs) with 95% confidence intervals (CIs). Restricted cubic spline (RCS) curves were utilized to assess linear associations. Stratified and interaction analyses were performed. Results We find that higher CMI is strongly associated with an increased risk of all-cause mortality ( p = 0.005) and cardiovascular mortality ( p = 0.020) in the strictest model. RCS analysis revealed a linear relationship between CMI and mortality. Subgroup and interaction analysis showed no statistical significance. Conclusions The higher CMI level is correlated with all-cause and cardiovascular mortality risk among young individuals with diabetes mellitus, and serves as a comprehensive and effective prognostic indicator for long-term health.
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Li et al. (2026) conducted a cohort in Type 2 diabetes mellitus (n=2,188). Cardiometabolic index (CMI) was evaluated on All-cause mortality and cardiovascular mortality (p=0.005 (all-cause), 0.020 (cardiovascular)). A higher cardiometabolic index is strongly associated with an increased risk of all-cause mortality and cardiovascular mortality among young adults with diabetes.
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