January 1, 1996Journal of Cell Science

The carboxyl terminus of myosin binding protein C (MyBP-C, C-protein) specifies incorporation into the A-band of striated muscle

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Population

Cultures of skeletal muscle myoblasts

Design

Preclinical

Authors

RGRénald GilbertCornell University MKMichael KellyCommonwealth Scientific and Industrial Research Organisation TMTakashi MikawaBay Institute

Discussion

Member takes

Implication

Does not inform clinical decisions; leaves open MyBP-C domain requirements for sarcomere assembly in human models.

Structured PICO

Population

Cultures of skeletal muscle myoblasts

Intervention

Transfection with expression plasmids encoding seven truncation mutants of MyBP-C (with a myc epitope)

Outcome

Targeting to the A-band investigated by immunofluorescence microscopysurrogate

The myosin binding domain of MyBP-C (motif X) is essential but not sufficient for correct incorporation into the A-band, requiring motifs VII to IX as well.

Cite This Study

Gilbert et al. (1996) studied this question.

synapsesocial.com/papers/6a109a98d478ddac0ffd41fd https://doi.org/10.1242/jcs.109.1.101

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The carboxyl terminus of myosin binding protein C (MyBP-C, C-protein) specifies incorporation into the A-band of striated muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The carboxyl terminus of myosin binding protein C (MyBP-C, C-protein) specifies incorporation into the A-band of striated muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider