Key result
Carbon-11 hydroxyephedrine PET imaging demonstrated significantly reduced absolute myocardial retention in patients with dilated cardiomyopathy compared to healthy controls (6.2 vs 10.7 %/min; p<0.001).
Why the study?
Does PET imaging with carbon-11 hydroxyephedrine reveal regional patterns of myocardial sympathetic denervation in patients with dilated cardiomyopathy compared to healthy controls?
Population
29 patients suffering from dilated cardiomyopathy with moderate to severe heart failure, and 8 healthy…
Comparison
Positron emission tomography imaging with… vs Healthy controls
Design
Case-control
Authors
Loading...
Supports sympathetic PET research in DCM; leaves open prognostic or therapeutic utility.
Case-Control (n=37)
Does PET imaging with carbon-11 hydroxyephedrine reveal regional patterns of myocardial sympathetic denervation in patients with dilated cardiomyopathy compared to healthy controls?
Absolute Event Rate: 6.2% vs 10.7%
p-value: p=< 0.001
PET imaging with carbon-11 hydroxyephedrine demonstrates both global and regional abnormalities in cardiac sympathetic innervation in patients with dilated cardiomyopathy, which correlate with disease severity.
Hartmann et al. (1999) conducted a case-control in Dilated cardiomyopathy with moderate to severe heart failure (n=37). Carbon-11 hydroxyephedrine (HED) PET imaging vs. Healthy controls was evaluated on Absolute myocardial HED retention (%/min) (p=< 0.001). Carbon-11 hydroxyephedrine PET imaging demonstrated significantly reduced absolute myocardial retention in patients with dilated cardiomyopathy compared to healthy controls (6.2 vs 10.7 %/min; p<0.001).