Key result
Plasma metabolomic profiling identifies 46 metabolites linked to incident CHD in African American individuals.
Why the study?
African American individuals have disproportionate CHD rates but lower CAC levels than non-Hispanic White individuals, and may have distinct metabolite profiles associated with incident CHD risk.
Are specific plasma metabolites associated with incident coronary heart disease and coronary artery calcium in African American individuals?
Population
2346 African American participants in JHS and 1588 multiethnic postmenopausal women in WHI
Comparison
Targeted plasma metabolite levels
Design
Prospective population-based cohort study with replication cohort
Authors
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These CHD-metabolite associations in African Americans are hypothesis-generating; prospective studies needed to assess prediction, causality, and clinical utility.
Cohort (n=3,934)
Yes
Are specific plasma metabolites associated with incident coronary heart disease and coronary artery calcium in African American individuals?
Specific plasma metabolites, including N-acylamides, leucine, and lipid species, are associated with incident coronary heart disease in African American individuals, with 13 metabolites successfully replicated in a multiethnic cohort.
Cruz et al. (2021) conducted a cohort in Coronary Heart Disease (n=3,934). Plasma metabolomic profiling was evaluated on Incident CHD. Plasma metabolomic profiling identified 46 metabolites associated with incident coronary heart disease in African American individuals, including 13 metabolites that were replicated in a multiethnic cohort.
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