Key result
Novel metabolomics score linked to ~0.88 unit higher LS7 score per SD in Black adults.
Why the study?
Black adults suffer from disparate levels of CVD risk factors but remain understudied, and the metabolomic profiles underlying cardiovascular health in this population needed to be defined.
Are specific plasma metabolomic profiles associated with ideal cardiovascular health (Life's Simple 7 score) in Black adults without known CVD?
Population
375 Black adults without known CVD
Comparison
Metabolomic profiles associated with AHA Life's Simple 7 score
Design
Cohort study
Authors
Loading...
Metabolomic signatures may refine CV risk insights in Black adults; hypothesis-generating and requires prospective validation before clinical use.
Cross-Sectional (n=375)
Yes
Are specific plasma metabolomic profiles associated with ideal cardiovascular health (Life's Simple 7 score) in Black adults without known CVD?
Mean Difference: 0.88 (95% CI 0.69–1.08)
p-value: p=5.69E-17
A novel metabolomics risk score based on pathways central to nitrogen balance, bioenergetics, and gluconeogenesis is significantly associated with ideal cardiovascular health in Black adults.
Islam et al. (2024) conducted a cross-sectional in Cardiovascular health (n=375). Metabolomics risk score vs. Lower metabolomics risk score was evaluated on Life's Simple 7 (LS7) score (Beta 0.88, 95% CI 0.69-1.08, p=5.69E-17). A one standard deviation increase in a novel metabolomics risk score was associated with a 0.88 unit higher Life's Simple 7 score in Black adults without known cardiovascular disease.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: