Automatic atrial sensitivity adjustment significantly improved the automatic mode switching response during atrial fibrillation from 1.7% to 50.6% at a starting sensitivity of 3.5 mV (P<0.05).
Observational (n=14)
Does automatic atrial sensitivity adjustment improve automatic mode switching response and reduce AF undersensing in patients with paroxysmal AF?
Automatic atrial sensitivity adjustment enhances atrial fibrillation sensing and improves the efficacy of automatic mode switching in dual chamber pacemakers, particularly when P wave sensing is borderline.
Absolute Event Rate: 50.6% vs 1.7%
p-value: p=< 0.05
Automatic mode switching (AMS) during atrial fibrillation (AF) in a dual chamber pacemaker is dependent on the accurate detection of an atrial electrogram. As atrial amplitude is often reduced during AF compared with sinus rhythm, this may result in failure of the AMS and a rapid ventricular response. In addition, undersensing of AF may result in competitive atrial pacing that sustains AF. We hypothesize that the use of automatic atrial sensitivity adjustment (ASA) may enhance AF sensing in a dual chamber pacemaker. We studied the AMS response with and without ASA of the Marathon DDDR (model 294-09, Intermedics, Inc.) pacemaker in 10 patients with paroxysmal AF. Intracardiac atrial electrograms during sinus rhythm and induced AF were recorded onto an analog tape recorder. They were replayed into the pacemaker to assess the AMS response at various starting atrial sensitivities from 3.5 to 0.8 mV with ASA activated and without. Atrial amplitude was reduced during AF. The higher the initial atrial sensitivity, the better is the AMS response and the lower the incidence of AF undersensing. The percentage of AMS before ASA ranged from 2.1% at an atrial sensitivity 3.5 mV to 95.6% at highest sensitivity of 0.5 mV (P < 0.05). After 10 minutes of ASA, the AMS response was improved from 1.7% to 50.6% and from 9.5% to 50.9% at starting atrial sensitivities of 3.5 mV and 2.5 mV, respectively (P < 0.05 in both instances). Undersensing during AF was also significantly reduced after ASA from 70% to 10% at a sensitivity of 3.5 mV and from 33.8% to 10.8% at 2.5 mV. There was no increase in oversensing. In four patients with paroxysmal AF with an implanted pacemaker, ASA improved AMS response in patients with a low implant atrial amplitude. In conclusion, efficacy of mode switching and AF sensing are dependent on the programmed atrial sensitivity, which can be enhanced with the use of ASA, particularly when P wave sensing during AF is borderline.
Lam et al. (Fri,) conducted a observational in Paroxysmal atrial fibrillation (n=14). Automatic atrial sensitivity adjustment (ASA) vs. Without ASA was evaluated on Automatic mode switching (AMS) response at starting atrial sensitivity of 3.5 mV (p=< 0.05). Automatic atrial sensitivity adjustment significantly improved the automatic mode switching response during atrial fibrillation from 1.7% to 50.6% at a starting sensitivity of 3.5 mV (P<0.05).