Why the study?
Cardiovascular diseases are increasing worldwide, prompting investigation into the association of total body water, total fat percent, and trunk fat percent with ECG parameters.
Cross-Sectional (n=3,217)
No
Body fat percentage and fat distribution are associated with specific ECG parameter changes, particularly in individuals with metabolic dysfunction, suggesting potential utility in cardiovascular risk screening.
Answers are grounded in this paper and cite their sources.
Should not yet inform ECG interpretation or screening; hypothesis-generating for body composition-ECG links in cross-sectional data.
Cardiovascular diseases as the leading cause of death and disability are increasing worldwide. The present study aimed to investigate the association between total body water, total fat percent, and trunk fat percent with electrocardiogram (ECG) parameters in the Persian Fasa Adult Cohort Study (FACS). This cross-sectional study was performed on the baseline information obtained from 3217 35–70-year-old participants of the FACS, southern Iran. Various ECG and body composition parameters were obtained from the FACS baseline database. Independent t-test, Chi-square test and linear regression were used for data analysis. Total body water (TBW) was positively associated with QRS length in men and women, and with PD and PR interval in women, exclusively. Additionally, in participants without chronic diseases (healthy group), TBW was shown to be positively associated with QRS length and PD; however, it was associated with QRS length and S wave in V3 lead (SV3) among those with type two diabetes, hypertension or ischemic heart disease (defined as unhealthy group). Total body fat percent (TBFP) was linearly associated with SV3 in unhealthy group. None of the studied ECG parameters was associated with TBFP in men, women and healthy group. Moreover, trunk fat percent was shown to be positive associated with R wave in aVL lead in women and unhealthy groups. Body fat percentage and fat distribution may affect ECG parameters, and subsequently associated with cardiovascular diseases, such as arrhythmias. Thus, these indicators may carry the potential for screening high-risk individuals.
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Sharafi et al. (2025) conducted a cross-sectional in General adult population (healthy and with chronic diseases) (n=3,217). Body composition components (Total body water, total body fat percent, trunk fat percent) was evaluated on Association between total body water (TBW) and QRS length in women (β 0.303, 95% CI 0.06, 0.54, p=0.012).
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