Key result
Metabolic syndrome is linked to ~56% higher odds of multiple ECG abnormalities in men.
Why the study?
Metabolic syndrome is an increasingly prevalent set of cardiac risk factors, but its relationship with ECG parameters and abnormalities as subclinical cardiovascular disease indicators required investigation.
Does metabolic syndrome and its components associate with ECG parameters and abnormalities in an Iranian rural population?
Cross-Sectional (n=6,958)
Does metabolic syndrome and its components associate with ECG parameters and abnormalities in an Iranian rural population?
Odds Ratio: 1.561 (95% CI 1.141–2.135)
p-value: p=0.005
Metabolic syndrome, particularly increased waist circumference and blood pressure, is associated with subclinical ECG abnormalities such as prolonged P duration, QRS duration, and QTc interval, highlighting its role in early cardiovascular risk.
May support ECG monitoring for early risk in men with metabolic syndrome; hypothesis-generating, needs prospective validation.
BACKGROUND: Metabolic syndrome (MetS) as a set of cardiac risk factors and its growing prevalence is one of the major concerns in different societies. In this study, we aimed to investigate the relationship between Mets and electrocardiogram (ECG) parameters and abnormalities as indicators for subclinical cardiovascular diseases (CVD). METHODS: In this sub-analysis study, we used the data from Fasa PERSIAN Cohort Study which includes subjects age 35-70 years. Subjects with available ECG data included in the study (n=7002) and subjects with missing data on MetS components and non-sinus rhythm ECG were excluded (n=44). The MetS definition based on the Adult Treatment Panel (ATP) III guidelines and also a 12-lead ECG was obtained from all participants. RESULTS: Our study population (n=6958) showed a mean age of 48.60±9.34 years and also 1656 (24.2%) subjects had MetS. Except for P duration, PR interval and S amplitude in men and P amplitude, S amplitude, Sokolow-Lyon Index, and QT interval in women, other ECG parameters differ significantly between subjects with and without Mets (P<0.05). Also among ECG abnormalities, prolonged P duration (≥120ms), QRS duration (≥100ms), and QTc interval (>450ms in male, >470ms in female) had a significant association with MetS in the total population. Waist circumferences (WC) showed the most count of significant relationship with ECG parameters in both genders. In males, WC more than ATP cut-points had significant associations with prolonged P and QRS duration, and also blood pressure (BP) had significant associations with prolonged P and QRS durations and QTc interval. In females, the MetS component except triglyceride had at least a significant relationship with prolonged P and/or QRS duration. CONCLUSION: MetS and its component especially WC and BP were associated with ECG parameters and abnormalities. These associations with ECG as a marker of subclinical CVD showed the importance of MetS and each component in our population to monitor in the further longitudinal studies.
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Yazdanpanah et al. (2020) conducted a cross-sectional in Metabolic Syndrome (n=6,958). Metabolic syndrome vs. Subjects without metabolic syndrome was evaluated on Multiple ECG abnormalities in males (OR 1.561, 95% CI 1.141-2.135, p=0.005). Metabolic syndrome was significantly associated with a 56% increased odds of having multiple electrocardiogram abnormalities in men (OR 1.561).
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