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February 1, 2000The Journal of Immunology242 citations

NK Markers on Virus-Specific CD8+ and CD4+ T Cells

NK Markers Are Expressed on a High Percentage of Virus-Specific CD8+ and CD4+ T Cells

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Authors

MSMark K. SlifkaRPRobb R. PagariganJWJ. Lindsay Whitton

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Overview

Reveals NK marker expression on T cells after viral infection, suggesting lineage similarities.

Key Points

  • To investigate the expression of NK markers on virus-specific CD8+ and CD4+ T cells post-viral infection.
  • Analyzed NK marker expression on T cells after acute viral infection.
  • Depleted NK cells in vivo using anti-ASGM1 antibody and assessed the effects on virus-specific T cells.
  • Over 90% of virus-specific CD8+ and CD4+ T cells coexpress NK markers from 5 to 500 days post-infection.
  • In vivo depletion of NK cells reduced virus-specific CD8+ T cells by 90% and CD4+ T cells by 50-80%.
  • Results indicate potential misinterpretation of studies using NK cell depletion due to impacts on virus-specific T cells.
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Cite This Study

Slifka et al. (2000) studied this question.

synapsesocial.com/papers/6a10b58a326831f8a2644745https://doi.org/10.4049/jimmunol.164.4.2009
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