August 1, 1999Journal of Applied Physiology
Daytime blood pressure elevation after nocturnal hypoxia
Why the study?
Does overnight exposure to hypoxia cause daytime blood pressure elevation in healthy normotensive subjects?
Population
10 healthy normotensive subjects
Comparison
Two consecutive nights of sleep for 8 hours in a… vs Two normoxic nights of sleep in the hypobaric…
Follow-up
4 hours post-exposure
Authors
Discussion
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Member takes
Implication
May link nocturnal hypoxia to transient diastolic BP elevation; hypothesis-generating for sleep apnea mechanisms.
Structured PICO
Does overnight exposure to hypoxia cause daytime blood pressure elevation in healthy normotensive subjects?
P
Population
10 healthy normotensive subjects
I
Intervention
Two consecutive nights of sleep for 8 hours in a hypobaric chamber at a simulated altitude of 4,000 m (barometric pressure = 462 mmHg)
C
Comparator
Two normoxic nights of sleep in the hypobaric chamber at ambient barometric pressure (745 mmHg)
O
Outcome
Daytime blood pressure (BP) measured every 5 minutes for 4 hours after return to baseline altitudesurrogate
Nocturnal hypoxia leads to a transient carryover elevation of daytime diastolic blood pressure, providing physiological insight into the cardiovascular effects of conditions like sleep apnea.
Cite This Study
Arabi et al. (1999) studied this question.