Key result
CMR reference values reveal larger ventricular volumes and mass in healthy males versus females.
Why the study?
Sex- and age-specific normal CMR reference values from large, multi-ethnic datasets using anatomically correct contouring were lacking.
Cohort (n=3,206)
Yes
p-value: p=<0.001
This study provides accurate sex and age-specific normal reference values for CMR parameters derived from a large, multi-ethnic population free of cardiovascular disease.
Sex-specific CMR reference values may refine interpretation in healthy adults; extends prior norms to large multi-ethnic cohort.
BACKGROUND: Despite the growing utility of cardiovascular magnetic resonance (CMR) for cardiac morphology and function, sex and age-specific normal reference values derived from large, multi-ethnic data sets are lacking. Furthermore, most available studies use a simplified tracing methodology. Using a large cohort of participants without history of cardiovascular disease (CVD) or risk factors from the Canadian Alliance for Healthy Heart and Minds, we sought to establish a robust set of reference values for ventricular and atrial parameters using an anatomically correct contouring method, and to determine the influence of age and sex on ventricular parameters. METHODS AND RESULTS: Participants (n = 3206, 65% females; age 55.2 ± 8.4 years for females and 55.1 ± 8.8 years for men) underwent CMR using standard methods for quantitative measurements of cardiac parameters. Normal ventricular and atrial reference values are provided: (1) for males and females, (2) stratified by four age categories, and (3) for different races/ethnicities. Values are reported as absolute, indexed to body surface area, or height. Ventricular volumes and mass were significantly larger for males than females (p < 0.001). Ventricular ejection fraction was significantly diminished in males as compared to females (p < 0.001). Indexed left ventricular (LV) end-systolic, end-diastolic volumes, mass and right ventricular (RV) parameters significantly decreased as age increased for both sexes (p < 0.001). For females, but not men, mean LV and RVEF significantly increased with age (p < 0.001). CONCLUSION: Using anatomically correct contouring methodology, we provide accurate sex and age-specific normal reference values for CMR parameters derived from the largest, multi-ethnic population free of CVD to date. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, NCT02220582. Registered 20 August 2014-Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02220582 .
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Luu et al. (2022) conducted a cohort in Healthy (No Cardiovascular Disease) (n=3,206). Cardiovascular magnetic resonance (CMR) was evaluated on Ventricular volumes and mass differences between sexes (p=<0.001). Cardiovascular magnetic resonance in 3,206 healthy adults established normal reference values, revealing that ventricular volumes and mass were significantly larger in males than females.
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