What is the clinical evidence from this study?

Study design: Cohort. Population: Healthy adults (n=685). Intervention: Computer-aided CMR analysis. Primary outcome: Sex-specific reference values for left ventricular volumes, mass, and ejection fraction.

What question did this study set out to answer?

To establish sex-specific reference values for left ventricular volumes, mass, and ejection fraction using computer-aided cardiovascular magnetic resonance analysis, and to evaluate the impact of age on these parameters.

October 7, 2013Journal of Magnetic Resonance ImagingOpen Access

CMR reference values for left ventricular volumes, mass, and ejection fraction using computer‐aided analysis: The Framingham Heart Study

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Key result

Computer-aided CMR analysis in healthy adults revealed men have greater LV volumes and mass (P=0.001), while women have greater ejection fraction (73% vs 71%; P=0.0002).

Key Points

To establish sex-specific reference values for left ventricular volumes, mass, and ejection fraction using computer-aided cardiovascular magnetic resonance analysis, and to evaluate the impact of age on these parameters.
Analyzed short-axis stack cine SSFP CMR data from 1,494 Framingham Heart Study Offspring cohort participants.
Identified a healthy reference subgroup of 685 adults free from cardiovascular disease, hypertension, or left ventricular wall motion abnormalities.
Calculated sex-specific 95th percentile cutoffs for volumes and mass, lower 5th percentile cutoffs for ejection fraction using computer-assisted border detection, and analyzed trends across age decades.
Men exhibited larger left ventricular volumes and mass than women, both before and after body size indexation (all P = 0.001), while women had higher ejection fractions (73 ± 6% vs. 71 ± 6%, P = 0.0002).
Left ventricular volumes decreased while ejection fraction and concentricity increased with advancing age across both sexes.
Indexed left ventricular mass remained stable across age groups despite differing significantly between sexes.

Study Design

Type

Cohort (n=685)

Structured PICO

Population

685 healthy adults (without cardiovascular disease, hypertension, or LV wall motion abnormality) from the Framingham Heart Study Offspring cohort, mean age 61 ± 9 years, 423 females.

Intervention

Short-axis stack cine SSFP CMR with computer-assisted border detection

Outcome

Sex-specific reference values (upper 95th percentile thresholds for LV volumes and mass, and lower 5th percentile thresholds for EF)surrogate

CMR-derived LV reference values show significant age and sex differences in LV volumes, EF, and geometry, highlighting the need for age- and sex-specific thresholds in clinical practice.

Discussion

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Implication

Supports sex-specific CMR reference values in reporting; leaves open impact on diagnostic accuracy or outcomes.

Cite This Study

Chuang et al. (2013) conducted a cohort in Healthy adults (n=685). Computer-aided CMR analysis was evaluated on Sex-specific reference values for left ventricular volumes, mass, and ejection fraction. Computer-aided CMR analysis in healthy adults revealed men have greater LV volumes and mass (P=0.001), while women have greater ejection fraction (73% vs 71%; P=0.0002).

synapsesocial.com/papers/6a11d31535a4eec8fedce8b1 https://doi.org/10.1002/jmri.24239

Topics

Cardiac MRI

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CMR reference values for left ventricular volumes, mass, and ejection fraction using computer‐aided analysis: The Framingham Heart Study

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Topics

CMR reference values for left ventricular volumes, mass, and ejection fraction using computer‐aided analysis: The Framingham Heart Study

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

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