Key result
Greater state anxiety was associated with higher sympathetic activity (PEP β = -0.24, P=0.02), while greater trait anxiety and depressive symptoms correlated with lower parasympathetic activity.
Why the study?
Are anxiety and depressive symptoms associated with an adverse cardiac autonomic profile in perimenopausal and postmenopausal women with hot flashes?
Population
121 peri- and postmenopausal women with hot flashes
Design
Cohort
Follow-up
12 weeks
Authors
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May indicate autonomic-mediated CV vulnerability in symptomatic midlife women; leaves open whether anxiety treatment modifies risk.
Observational (n=121)
Are anxiety and depressive symptoms associated with an adverse cardiac autonomic profile in perimenopausal and postmenopausal women with hot flashes?
Effect estimate: β = -0.24
p-value: p=0.02
Increased anxiety and depressive symptoms in midlife women with hot flashes are associated with an unfavorable cardiac autonomic profile, potentially increasing cardiovascular risk.
Fu et al. (2018) conducted an observational in Perimenopausal and postmenopausal women with hot flashes (n=121). Anxiety and depressive symptoms was evaluated on Pre-ejection period (PEP) and respiratory sinus arrhythmia (RSA) (β = -0.24, p=0.02). Greater state anxiety was associated with higher sympathetic activity (PEP β = -0.24, P=0.02), while greater trait anxiety and depressive symptoms correlated with lower parasympathetic activity.
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