Patient randomised controlled trial of technology enabled strategies to promote treatment adherence in liver transplantation: rationale and design of the TEST trial

Marina Serper; Alex Burdzy; Douglas E. Schaubel; R. C. Mason; Arpita Banerjee; David S. Goldberg; Éric Martin; Shivan J. Mehta; Louise B. Russell; Amanda Cheung; Daniela P. Ladner; Julia Yoshino Benavente; Michael S. Wolf

doi:10.1136/bmjopen-2023-075172

September 1, 2023BMJ OpenOpen Access

Patient randomised controlled trial of technology enabled strategies to promote treatment adherence in liver transplantation: rationale and design of the TEST trial

View Full Paper

Ask AI

Bookmark

Share

Key Points

To describe the rationale and design of the TEST trial, which evaluates whether a remotely administered digital adherence program improves treatment adherence compared with usual care in liver transplant recipients.
Patient-randomized prospective clinical trial conducted across three transplant centers in the Northeast, Midwest, and South (NCT05260268).
Intervention delivers text message prompts, reminders, and non-adherence phenotyping (cognitive, psychological, medical, social, or economic) alongside routine self-management support versus standard care.
Primary endpoint is medication adherence measured via 24-hour recall, with secondary outcomes including ASK-12 scores, tacrolimus levels, quality of life, and hospital days.
Trial design establishes protocols to evaluate differences in 24-hour recall medication adherence between the digital intervention and standard care arms.
Planned secondary analyses focus on assessing graft-related clinical outcomes, regimen knowledge, health status, and cost-effectiveness.

No abstract yet

We only have this paper's title and publication details.

Read it at the source

Implication

Randomized trial reports a digital monitoring protocol for liver transplant recipients, highlighting tech-enabled strategies to prevent graft rejection.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Serper et al. (2023) studied this question.

synapsesocial.com/papers/6a10bf0439dd87f6d0ee4376 https://doi.org/10.1136/bmjopen-2023-075172

View Full Paper

Ask AI

Bookmark

Share

Patient randomised controlled trial of technology enabled strategies to promote treatment adherence in liver transplantation: rationale and design of the TEST trial

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Patient randomised controlled trial of technology enabled strategies to promote treatment adherence in liver transplantation: rationale and design of the TEST trial

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Keep reading

Keep reading