Strategy of non-drug management of metabolic syndrome, which is accompanied by prediabetes and hypertension

Background. The condition of prediabetes implies the possibility to achieve stable normal glycemic indicators in order to prevent the further development of diabetes without using drug therapy. The effectiveness and safety of herbal cardioprotectors in metabolic syndrome accompanied by prediabetes is being comprehensively studied all over the world. The purpose was to determine and study the possibilities of influence of natural cardioprotector, on indicators of carbohydrate and lipid metabolism, as well as on blood pressure in patients with metabolic syndrome. Materials and methods. Patients were divided into 3 groups: in the first one (control group), diet therapy and physical activity were prescribed, in the second and third — diet therapy, physical activity and herbal cardioprotector in different dosages. Fasting glucose and glycated hemoglobin (HbA1C), lipidogram and blood pressure were monitored, the quality of life index was assessed before treatment, after 4 and 8 weeks. The quality of life index was estimated by the sum of points self-reported by patients on the EQ-5D-5L questionnaire. Results. Conducted clinical observations in three selected groups showed the ability of natural cardioprotector to harmonize the indicators of lipidogram with a tendency to reach the norm and to reduce fasting blood glucose and HbA1C. In study group 2, in which patients took 2 capsules of herbal medicine twice daily, there was a more pronounced shift towards normalization of low- and high-density lipoproteins, total cholesterol and triglycerides. Also, in this group compared to study group 1 and control group, a more pronounced tendency to blood pressure normalization and a more significant hypoglycemic effect were recorded: a decrease in fasting glucose from 6.22 ± 0.13 to 5.22 ± 0.08 mmol/l (р < 0.05), which allows us to reasonably assume the existence of a certain dose-dependent effectiveness of cardioprotector. Conclusions. Herbal cardioprotector has shown effectiveness in the non-medicinal correction of metabolic syndrome manifestations and, first of all, prediabetes. Due to the high safety profile of the natural active ingredients of herbal remedy, practitioners can fully use the potential of non-pharmacological correction of prediabetes.