Key result
Treatment with an ACEI or ARB decreased high-glucose-induced senescence and apoptosis via the RAS-mitochondria pathway in endothelial cells.
Why the study?
Do ACEIs or ARBs reduce senescence and apoptosis in high-glucose-induced endothelial cells?
Population
High-glucose-induced endothelial cells, diabetic rats, and diabetic patients
Comparison
Angiotensin-converting enzyme inhibitors or… vs Untreated high-glucose conditions or untreated…
Design
Preclinical
Authors
Loading...
May protect endothelial cells in hyperglycemia models; leaves open translation to human diabetes trials.
Do ACEIs or ARBs reduce senescence and apoptosis in high-glucose-induced endothelial cells?
ACEIs and ARBs protect against high-glucose-induced endothelial cell senescence and apoptosis by modulating autophagy and RAS-mitochondrial pathways.
Chen et al. (2014) studied Diabetes / High-glucose-induced endothelial damage. ACEI or ARB vs. High glucose / Angiotensin II was evaluated on Senescence, apoptosis, and autophagic responses. Treatment with an ACEI or ARB decreased high-glucose-induced senescence and apoptosis via the RAS-mitochondria pathway in endothelial cells.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: