January 1, 2018Cellular Physiology and BiochemistryOpen Access

Resveratrol Modulates Apoptosis and Autophagy Induced by High Glucose and Palmitate in Cardiac Cells

View Full Paper

Ask AI

Bookmark

Population

H9c2 cardiac myoblast cells exposed to high glucose combined with palmitate

Comparison

Resveratrol vs High glucose and palmitate without resveratrol

Design

Preclinical

Authors

KXKui XuCity Of Hope National Medical Center XLXiufen LiuJilin University ZKZhiqiang KeHubei University of Science and Technology

Discussion

Member takes

Implication

Resveratrol effects in diabetic H9c2 cells remain hypothesis-generating; leaves open any clinical translation.

Structured PICO

Population

H9c2 cardiac myoblast cells exposed to high glucose combined with palmitate

Intervention

Resveratrol

Comparator

High glucose and palmitate without resveratrol (implied control)

Outcome

Autophagy (LC3-II/I ratio, P62 protein levels, LC3 fluorescent puncta) and apoptosis (TUNEL, flow cytometry, cleavage of caspase-3 and PARP)surrogate

Resveratrol protects cardiac cells from high glucose and palmitate-induced apoptosis by restoring autophagy via AMPK and JNK1 pathways, suggesting a potential mechanism for treating diabetic cardiomyopathy.

Cite This Study

Xu et al. (2018) studied this question.

synapsesocial.com/papers/6a7976fb8a3ae1c74232383e https://doi.org/10.1159/000489442

View Full Paper

Ask AI

Bookmark

Resveratrol Modulates Apoptosis and Autophagy Induced by High Glucose and Palmitate in Cardiac Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Resveratrol Modulates Apoptosis and Autophagy Induced by High Glucose and Palmitate in Cardiac Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider