Why the study?
Does resveratrol prevent renal damage in type 2 diabetic db/db mice?
Population
Male C57 BLKS/J db/m and db/db mice and human glomerular endothelial cells
Comparison
Resveratrol administered by oral gavage for 12… vs Untreated diabetic mice and nondiabetic mice
Design
Preclinical
Follow-up
12 weeks
Key result
Resveratrol significantly reduced 24-hour albuminuria (30.1 vs 140.0 μg/day) and ameliorated renal damage in type 2 diabetic mice by increasing AdipoR1 and AdipoR2 expression.
Authors
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Resveratrol shows promise in preclinical diabetic nephropathy models; leaves open translation to clinical use pending human trials.
Does resveratrol prevent renal damage in type 2 diabetic db/db mice?
Absolute Event Rate: 30.1% vs 140%
Resveratrol prevents diabetic nephropathy in a mouse model by ameliorating lipotoxicity, oxidative stress, and apoptosis via increasing AdipoR1 and AdipoR2 expression.
Park et al. (2016) studied Type 2 diabetic nephropathy (n=32). Resveratrol vs. 0.5% carboxymethyl cellulose sodium salt (CMC) was evaluated on 24-h albuminuria (μg/day). Resveratrol significantly reduced 24-hour albuminuria (30.1 vs 140.0 μg/day) and ameliorated renal damage in type 2 diabetic mice by increasing AdipoR1 and AdipoR2 expression.
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