Why the study?
Does resveratrol attenuate diabetic nephropathy and modulate angiogenesis in a type 1 diabetic rat model?
Population
60 Sprague-Dawley male rats weighing 180-200g, uninephrectomized, with streptozocin-induced type 1 diabetes…
Comparison
Resveratrol 20 mg/kg body weight/day via gavage… vs Diabetic nephropathy control group receiving…
Design
Preclinical, randomly divided into three groups
Follow-up
8 weeks
Authors
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Resveratrol attenuates albuminuria in diabetic rats; hypothesis-generating and requires human trials before any clinical consideration.
Does resveratrol attenuate diabetic nephropathy and modulate angiogenesis in a type 1 diabetic rat model?
In a rat model of type 1 diabetes, resveratrol attenuated diabetic nephropathy by modulating angiogenesis and reducing VEGF/Flk-1 expression via a Sirt1-dependent mechanism.
Wen et al. (2013) studied this question.
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