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August 9, 2026HereditasOpen Access

Resveratrol attenuates tubular injury in diabetic kidney disease by suppressing the ferroptosis–ferritinophagy pathway

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Authors

DZDongju ZhuLLLonghui Li

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Overview

Randomized trial demonstrates resveratrol reduces tubular injury in diabetic kidney disease, highlighting its potential therapeutic effects.

Key Points

  • This study aims to investigate the protective effects of resveratrol on renal tubular injury in diabetic kidney disease and its role in the ferroptosis-ferritinophagy pathway.
  • Established a diabetic kidney disease mouse model using unilateral nephrectomy and streptozotocin injection.
  • Divided 30 mice into groups treated with resveratrol at varying doses for 8 weeks and assessed renal function and injury markers.
  • Performed hematoxylin and eosin staining, Masson staining, immunofluorescence, and Western blotting for related proteins.
  • Resveratrol treatment significantly reduced fasting blood glucose, SCr, BUN, 24-hour urinary protein, and markers of oxidative stress (MDA, Fe²⁺).
  • Increased antioxidant levels including T-SOD and GSH-Px (P < 0.05).
  • Resveratrol modulated key proteins related to ferroptosis and ferritinophagy, indicating a dose-dependent protective effect.

Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/6a782d2c2e1896536c83ff98https://doi.org/10.1186/s41065-026-00718-2
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