What question did this study set out to answer?

To evaluate the effects of resveratrol supplementation on skeletal muscle SIRT1 expression and energy expenditure in patients with type 2 diabetes mellitus.

February 1, 2014International Journal of Sport Nutrition and Exercise Metabolism

Effects of Resveratrol in Patients with Type 2 Diabetes Mellitus on Skeletal Muscle SIRT1 Expression and Energy Expenditure

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Authors

KGKian Peng GohKhoo Teck Puat Hospital HLHwei Yee LeeTan Tock Seng Hospital DLDawn Pingxi LauNational Cancer Centre Singapore

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Implication

Randomized double-blind trial reveals that resveratrol increases skeletal muscle SIRT1 expression and resting metabolic rate in type 2 diabetes, suggesting potential exercise-mimetic effects.

Key Points

To evaluate the effects of resveratrol supplementation on skeletal muscle SIRT1 expression and energy expenditure in patients with type 2 diabetes mellitus.
Randomized, double-blind, placebo-controlled trial conducted in 10 patients with type 2 diabetes mellitus.
Participants received either 3 g of resveratrol or placebo daily for 12 weeks.
Resveratrol significantly increased skeletal muscle SIRT1 expression (2.01 vs. 0.86 AU, p = .016) and the p-AMPK to AMPK ratio (2.04 vs. 0.79 AU, p = .032) compared to placebo.
Resting metabolic rate increased following resveratrol compared to placebo in both percentage of absolute change (8.6% vs. -13.9%, p = .033) and percentage of predicted rate (7.8% vs. -13.9%, p = .013).
Average daily activity (-38% vs. 43.2%, p = .028) and daily step counts (-39.5% vs. 11.8%, p = .047) significantly decreased in the resveratrol group compared to placebo.

Cite This Study

Goh et al. (2014) studied this question.

synapsesocial.com/papers/6aa4cd176ab07c8cae8118e1 https://doi.org/10.1123/ijsnem.2013-0045

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Implication

Randomized double-blind trial reveals that resveratrol increases skeletal muscle SIRT1 expression and resting metabolic rate in type 2 diabetes, suggesting potential exercise-mimetic effects.

Effects of Resveratrol in Patients with Type 2 Diabetes Mellitus on Skeletal Muscle SIRT1 Expression and Energy Expenditure

Discussion

Member takes

Implication

Key Points

Cite This Study

Effects of Resveratrol in Patients with Type 2 Diabetes Mellitus on Skeletal Muscle SIRT1 Expression and Energy Expenditure

Discussion

Member takes

Implication

Key Points

Cite This Study

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