Key result
Antihypertensive treatment with beta-blockers or high-dose diuretics impairs insulin sensitivity, whereas alpha1-blockers, captopril, and moxonidine improve it in insulin-resistant patients.
Why the study?
How do different classes of antihypertensive drugs affect insulin sensitivity and the risk of developing diabetes in hypertensive patients?
How do different classes of antihypertensive drugs affect insulin sensitivity and the risk of developing diabetes in hypertensive patients?
Antihypertensive drug classes differ in their metabolic effects, suggesting that drugs improving or neutral to insulin sensitivity should be preferred in insulin-resistant patients to prevent diabetes.
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May inform antihypertensive selection in insulin-resistant patients; leaves open prospective validation on diabetes incidence.
Hans Lithell (1998) conducted a review in Hypertension and Insulin Resistance. Antihypertensive drugs was evaluated on Insulin sensitivity and development of diabetes. Antihypertensive treatment with beta-blockers or high-dose diuretics impairs insulin sensitivity, whereas alpha1-blockers, captopril, and moxonidine improve it in insulin-resistant patients.
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