November 14, 2002Circulation ResearchOpen Access

Phorbol Ester Induction of Angiotensin-Converting Enzyme Transcription Is Mediated by Egr-1 and AP-1 in Human Endothelial Cells via ERK1/2 Pathway

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Population

Human umbilical vein endothelial cells

Design

Preclinical

Authors

MEMélanie EyriesSorbonne Université MAMonique AgrapartInserm AAAmalia AlonsoUniversidad de Navarra

Discussion

Member takes

Implication

Does not support clinical translation; leaves open ERK1/2-Egr-1/AP-1 targeting in ACE-related disease.

Structured PICO

Population

Human umbilical vein endothelial cells

Intervention

Phorbol 12-myristate 13-acetate (PMA) stimulation, with or without PD98059 (MEK1 inhibitor)

Outcome

ACE gene transcription and expressionsurrogate

PMA induces ACE transcription in human endothelial cells through the activation of Egr-1 and AP-1 transcription factors via the ERK1/2 signaling pathway.

Cite This Study

Eyries et al. (2002) studied this question.

synapsesocial.com/papers/6a10cd6bed67694fb09f7636 https://doi.org/10.1161/01.res.0000042703.39845.b4

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Phorbol Ester Induction of Angiotensin-Converting Enzyme Transcription Is Mediated by Egr-1 and AP-1 in Human Endothelial Cells via ERK1/2 Pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Phorbol Ester Induction of Angiotensin-Converting Enzyme Transcription Is Mediated by Egr-1 and AP-1 in Human Endothelial Cells via ERK1/2 Pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider