January 1, 1989Journal of VirologyOpen Access

Construction and analysis of deletion mutations in the U5 region of Moloney murine leukemia virus: effects on RNA packaging and reverse transcription

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Population

Cloned DNA copies of Moloney murine leukemia virus or a related retrovirus, and cell lines expressing the…

Design

Preclinical

Authors

JMJohn E. MurphyUniversity Hospitals of Cleveland SGS P GoffColumbia University

Discussion

Member takes

Implication

Supports distinct U5 domains in MuLV replication; hypothesis-generating for retroviral vectors, needs validation beyond animal models.

Structured PICO

Population

Cloned DNA copies of Moloney murine leukemia virus or a related retrovirus, and cell lines expressing the mutant DNAs

Intervention

Deletion mutations in the U5 region

Outcome

RNA packaging and reverse transcriptionsurrogate

The study identifies distinct functional domains within the U5 region of the Moloney murine leukemia virus responsible for RNA packaging and reverse transcription.

Cite This Study

Murphy et al. (1989) studied this question.

synapsesocial.com/papers/6a10cf9839dd87f6d0ee5fbc https://doi.org/10.1128/jvi.63.1.319-327.1989

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Construction and analysis of deletion mutations in the U5 region of Moloney murine leukemia virus: effects on RNA packaging and reverse transcription

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Construction and analysis of deletion mutations in the U5 region of Moloney murine leukemia virus: effects on RNA packaging and reverse transcription

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider