Key result
Males predominantly present with right posteroseptal accessory pathways whereas females show left lateral pathways.
Why the study?
The etiology of accessory pathways is generally unknown, prompting this evaluation of the correlation between gender, accessory pathway location, and clinical presentation.
Does gender correlate with the anatomical location and clinical presentation of accessory pathways in patients undergoing radiofrequency ablation?
Observational (n=139)
No
Does gender correlate with the anatomical location and clinical presentation of accessory pathways in patients undergoing radiofrequency ablation?
p-value: p=0.025
Gender appears to influence the anatomical location of accessory pathways, with right posteroseptal pathways more common in males and left lateral pathways more common in females.
Gender may inform accessory pathway ablation planning; this Level 3 cohort finding leaves open outcome impacts and mechanisms.
Background Accessory pathways (APs) are muscular bundles capable of rapid conduction between atria and ventricles. They can be located anywhere along the atrioventricular groove or septum. The etiology of such pathways is generally unknown. This study aims to evaluate the correlation between gender, AP location, and clinical presentation. Methods This is a retrospective study of 139 patients who underwent radiofrequency ablations for newly diagnosed accessory pathways between years 2010 and 2016. Information extracted from the medical records included: age at the time of diagnosis, gender, characteristics, and anatomical location of the accessory pathways. Results A total of 139 patients with AP were enrolled in the study. The mean age of diagnosis was 32.2 ± 13.5 years. With regards to gender, APs were more common among men (p-value 0.04). Males were predominant in both the right and left AP groups (p-value 0.025), although, overall, most of the AP were left located. Also, males were more commonly diagnosed with right posteroseptal (RPS) accessory pathways while females with left lateral (LL) pathways. Concerning the clinical presentation, the manifest form was more frequent than concealed. Males were prevalent in both groups (p-value 0.38). Conclusion Gender components might have a role in the pathogenesis of AP formation.
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Rabah et al. (2021) conducted an observational in Accessory pathways (n=139). Male gender vs. Female gender was evaluated on Anatomical location of accessory pathways (p=0.025). Males more commonly presented with right posteroseptal accessory pathways, whereas females predominantly had left lateral pathways, demonstrating a significant gender difference in locations (p=0.025).
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