Observational data link accessory pathways to male sex; leaves open whether age or anatomy drive clinical risk.
There are many factors that explain this relation between APs and age, and one possible mechanical explanation may be differences in electrophysiological properties, such as conduction speed and refractory period of APs and atrio- ventricular nodes. The objective of this study was to evaluate the correlation between age groups and gender, presentation pattern (manifest or concealed) and anatomical distribution of APs. Although APs have a genetically mediated transmission model, there is no uniformity in their presentation, and differences can be observed in their distribution depending on gender and onset age, in clinical and electrocardiographic manifestations.
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Ferro et al. (2018) studied this question.
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