What question did this study set out to answer?

To establish the incidence rate and identify clinical risk factors for dementia in older individuals with clinically probable Parkinson's disease relative to community-based controls.

June 14, 2004Movement Disorders

Risk and incidence of dementia in a cohort of older subjects with Parkinson's disease in the United Kingdom

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To establish the incidence rate and identify clinical risk factors for dementia in older individuals with clinically probable Parkinson's disease relative to community-based controls.
Prospective cohort study of 86 non-demented Parkinson's disease patients aged over 65 years and 102 matched community controls recruited in the United Kingdom.
Subjects underwent clinical, cognitive, mood, and motor evaluations at baseline and at a 4-year follow-up using DSM-IV criteria and the Cambridge Cognitive Examination (CAMCOG).
At 4 years, dementia developed in 35.3% (18/51) of reassessed Parkinson's disease patients compared with 7.0% (5/72) of control participants.
The dementia incidence was 107.1 per 1,000 person-years (95% CI, 59.9–159.8) in Parkinson's disease versus 17.9 per 1,000 person-years (95% CI, 5.8–31.9) in controls, reflecting a relative risk of 5.1 (95% CI, 2.1–12.5).
Older age, later age at Parkinson's onset, longer symptom duration, hallucinations, and baseline memory and language deficits significantly predicted dementia development (P < 0.05).

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Implication

Cohort study reveals a fivefold increased risk of dementia in older individuals with Parkinson's disease, highlighting the need for tailored long-term clinical management.

Cite This Study

Hobson et al. (2004) studied this question.

synapsesocial.com/papers/6a10d32d63b25c787d9f8e7d https://doi.org/10.1002/mds.20216

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Implication

Cohort study reveals a fivefold increased risk of dementia in older individuals with Parkinson's disease, highlighting the need for tailored long-term clinical management.

Risk and incidence of dementia in a cohort of older subjects with Parkinson's disease in the United Kingdom

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Discussion

Implication

Cite This Study

Risk and incidence of dementia in a cohort of older subjects with Parkinson's disease in the United Kingdom

Key Points

Discussion

Implication

Cite This Study

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