What question did this study set out to answer?

Determine the incidence and clinical determinants of dementia in patients with Parkinson's disease compared to matched control subjects over a 54-month observation period.

July 1, 1992Journal of Neurology Neurosurgery & PsychiatryOpen Access

A controlled, longitudinal study of dementia in Parkinson's disease.

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Determine the incidence and clinical determinants of dementia in patients with Parkinson's disease compared to matched control subjects over a 54-month observation period.
Monitored a cohort of 87 patients with Parkinson's disease (PD) and 50 matched controls at 9-month intervals over 54 months.
Evaluated cognition, mood, and disability serially, diagnosing dementia using DSM-III-R criteria and calculating rates via survival analysis.
At baseline, 6% (5/87) of PD patients had dementia compared to 0% (0/50) of control subjects.
During follow-up, 10 additional PD patients met dementia criteria (cumulative incidence of 19%; 47.6 per 1,000 person-years), whereas 0 controls developed dementia.
PD patients who developed dementia were older at disease onset, had longer disease duration, and were older at baseline evaluation than those without dementia.

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Implication

Controlled cohort study observes elevated dementia incidence in Parkinson's disease, highlighting age at disease onset and duration as key clinical risk factors.

Cite This Study

Biggins et al. (1992) studied this question.

synapsesocial.com/papers/6a7570ebcbb3fa1e5bdbdf2d https://doi.org/10.1136/jnnp.55.7.566

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Implication

Controlled cohort study observes elevated dementia incidence in Parkinson's disease, highlighting age at disease onset and duration as key clinical risk factors.

A controlled, longitudinal study of dementia in Parkinson's disease.

Key Points

Discussion

Implication

Cite This Study

A controlled, longitudinal study of dementia in Parkinson's disease.

Key Points

Discussion

Implication

Cite This Study

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