Key result
Chemotherapy and radiotherapy in childhood cancer survivors carry a substantial risk for late cardiac effects, with cardiovascular events remaining the leading cause of death among survivors.
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Cardiovascular monitoring, prevention, and early detection of cardiac dysfunction are essential for improving long-term outcomes in adult survivors of childhood cancers.
Therapeutic advances in paediatric oncology allowed increasing numbers of children to survive until adulthood. However, chemotherapy and radiotherapy are potentially cardiotoxic and contribute to a significant morbidity and mortality, cardiovascular events remaining the leading cause of death among survivors. This review summarizes the physiopathology of treatment-related cardiovascular diseases, their incidence, and the risk factors associated with each specific therapy. Few studies have investigated the cardiac outcomes of adult surviving from childhood cancers but all demonstrated a substantial risk for late cardiac effects. Cardiovascular monitoring, prevention, and early detection of cardiac dysfunction are, therefore, the keystones of an improved long-term outcome.
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Goyet et al. (2012) conducted a review in Childhood cancer survivors. Chemotherapy and radiotherapy was evaluated. Chemotherapy and radiotherapy in childhood cancer survivors carry a substantial risk for late cardiac effects, with cardiovascular events remaining the leading cause of death among survivors.
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