Why the study?
Does cumulative anthracycline dose reduce left ventricular function in pediatric patients with malignant diseases?
Population
54 pediatric patients with a variety of malignant diseases
Comparison
Anthracycline chemotherapy at varying cumulative… vs Baseline or lower cumulative doses
Design
Cohort
Authors
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LV decline associated with >250 mg/m2 anthracyclines in children; leaves open refined monitoring thresholds pending prospective trials.
Does cumulative anthracycline dose reduce left ventricular function in pediatric patients with malignant diseases?
Anthracycline-induced cardiotoxicity in children becomes echocardiographically evident at cumulative doses >250 mg/m2, suggesting the need for serial echocardiographic monitoring.
Lewis et al. (1978) studied this question.
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