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April 1, 1988Archives of Internal Medicine

The Effect of ß-Blockers on Mental Performance on Older Hypertensive Patients

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Why the study?

Do beta-blockers (atenolol or metoprolol) affect mental performance and drowsiness in older hypertensive patients?

Population

27 older hypertensive patients, mean age 63 +/- 3 years

Comparison

Atenolol 100 mg daily or metoprolol tartrate 150… vs Placebo daily for two weeks

Design

RCT, double-blind

Follow-up

2 weeks per treatment period

Authors

FGFran M. Gengo

Discussion

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Overview

Metoprolol may enhance cognitive performance without excess lethargy in older hypertensives; extends evidence for agent-specific beta-blocker effects on mental function.

Structured PICO

Do beta-blockers (atenolol or metoprolol) affect mental performance and drowsiness in older hypertensive patients?

P
Population
27 older hypertensive patients, mean age 63 +/- 3 years
I
Intervention
Atenolol 100 mg daily or metoprolol tartrate 150 mg daily for two weeks each
C
Comparator
Placebo daily for two weeks
O
Outcome
Mental performance measured using Trails-A maze testing, and drowsiness measured subjectively (visual analogue scale) and objectively (critical fusion-frequency threshold testing)patient reported

Cite This Study

Fran M. Gengo (1988) studied this question.

synapsesocial.com/papers/6a10d964cfa01e990d9fa8a7https://doi.org/10.1001/archinte.1988.00380040019004
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