Key result
Cardiac magnetic resonance, including late gadolinium enhancement and T1 mapping, plays an increasingly important role in identifying, characterizing, and quantifying myocardial fibrosis in HCM.
Why the study?
What is the role of novel cardiac magnetic resonance techniques in assessing myocardial fibrosis and guiding clinical management in patients with hypertrophic cardiomyopathy?
What is the role of novel cardiac magnetic resonance techniques in assessing myocardial fibrosis and guiding clinical management in patients with hypertrophic cardiomyopathy?
CMR techniques, specifically LGE and T1 mapping, play an increasingly important role in assessing myocardial fibrosis in HCM, aiding in diagnosis, management, and prognosis.
May aid fibrosis assessment in HCM; leaves open prospective trials before guiding management.
Hypertrophic cardiomyopathy (HCM) is a primary myocardial disease caused by mutations in sarcomeric contractile proteins, characterized by cardiomyocytes disarray, interstitial fibrosis, increased arteriolar wall thickness and scarring. Fibrosis could represent a substrate for the generation of malignant ventricular tachyarrhythmias, which represent the current pathway for sudden cardiac death and is responsible for passive diastolic dysfunction, that is the leading cause of dyspnea. The aim of this review is to depict the increasingly role of cardiac magnetic resonance (CMR) for assessment of myocardial fibrosis in HCM. This article will briefly review the current status of the novel CMR techniques (the Late Gadolinium Enhancement and the emerging T1 mapping) for identification, characterization and quantization of myocardial fibrosis in HCM. In addition, this review will discuss the most recent acquisition techniques, the new parameters and their possible clinical utility in diagnosis, therapeutic management and prognosis in HCM.
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Carla Contaldi (2016) conducted a review in Hypertrophic cardiomyopathy (HCM). Cardiac magnetic resonance (CMR) was evaluated. Cardiac magnetic resonance, including late gadolinium enhancement and T1 mapping, plays an increasingly important role in identifying, characterizing, and quantifying myocardial fibrosis in HCM.
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