Influence of Race and Sex on Thrombogenicity in a Large Cohort of Coronary Artery Disease Patients
Key result
Female sex and black race independently increased platelet-fibrin clot strength in CAD patients, with women having greater MAKH than men (68.3 vs 65.8 mm, P<0.0001).
Why the study?
Do female sex and Black race increase thrombogenicity in patients with coronary artery disease on aspirin therapy?
Population
1,172 patients on aspirin therapy for 1 week or longer with known or suspected coronary artery disease…
Comparison
Female sex and Black race vs Male sex and White race
Design
Cross-sectional
Authors
Discussion
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Implication
May signal higher thrombotic risk in women and Black CAD patients; leaves open need for prospective validation before practice change.
Study Design
Type
Cohort (n=1,172)
Structured PICO
Do female sex and Black race increase thrombogenicity in patients with coronary artery disease on aspirin therapy?
P
Population
1,172 patients on aspirin therapy for 1 week or longer with known or suspected coronary artery disease undergoing nonurgent cardiac catheterization
I
Intervention
Female sex and Black race
C
Comparator
Male sex and White race
O
Outcome
Thrombin-induced platelet-fibrin clot strength (MAKH) measured by thrombelastographysurrogate
Main Result
Absolute Event Rate: 68.3% vs 65.8%
p-value: p=<0.0001
Female sex and Black race are independently associated with increased platelet-fibrin clot strength in CAD patients, suggesting a higher thrombogenicity profile that may confer increased risk for thrombotic events.
Cite This Study
Lev et al. (2014) conducted a cohort in Coronary artery disease (n=1,172). Female sex and Black race vs. Male sex and White race was evaluated on Thrombin-induced platelet-fibrin clot strength (MAKH) measured by thrombelastography (p=<0.0001). Female sex and black race independently increased platelet-fibrin clot strength in CAD patients, with women having greater MAKH than men (68.3 vs 65.8 mm, P<0.0001).