SPIN (Scottish Pregnancy Intervention) study: a multicenter, randomized controlled trial of low-molecular-weight heparin and low-dose aspirin in women with recurrent miscarriage

294 pregnant women presenting for initial antenatal care at <7 weeks' gestation with a history of 2 or more consecutive previous pregnancy losses at ≤24 weeks' gestation and no evidence of anatomic, endocrine, chromosomal, or immunologic abnormality.

Enoxaparin 40 mg subcutaneously and aspirin 75 mg orally once daily along with intense pregnancy surveillance from random assignment until 36 weeks' gestation.

Intense pregnancy surveillance alone from random assignment until 36 weeks' gestation.

Pregnancy loss ratehard clinical