Key result
Treatment with low dose aspirin and heparin significantly increased the rate of live births compared to aspirin alone (71% vs 42%; OR 3.37, 95% CI 1.40-8.10) in women with recurrent miscarriage.
Why the study?
Does low dose aspirin plus heparin improve the rate of live births in pregnant women with recurrent miscarriage associated with phospholipid antibodies compared to aspirin alone?
Population
90 pregnant women with a history of recurrent miscarriage and persistently positive results for phospholipid…
Comparison
Low dose aspirin and 5000 U of unfractionated… vs Low dose aspirin alone, started at positive…
Design
RCT, Randomly allocated an intervention when fetal heart activity was seen on…
Follow-up
Until delivery or miscarriage
Authors
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Supports adding heparin to aspirin for higher live births in antiphospholipid recurrent miscarriage; provides first RCT confirmation of benefit.
RCT (n=90)
randomly allocated
No
Does low dose aspirin plus heparin improve the rate of live births in pregnant women with recurrent miscarriage associated with phospholipid antibodies compared to aspirin alone?
Odds Ratio: 3.37 (95% CI 1.4–8.1)
Absolute Event Rate: 71% vs 42%
The addition of low dose heparin to low dose aspirin significantly improves the rate of live births in women with recurrent miscarriage associated with phospholipid antibodies.
Rai et al. (1997) conducted an RCT in recurrent miscarriage associated with phospholipid antibodies (n=90). low dose aspirin and heparin vs. low dose aspirin alone was evaluated on Rate of live births (OR 3.37, 95% CI 1.40 to 8.10). Treatment with low dose aspirin and heparin significantly increased the rate of live births compared to aspirin alone (71% vs 42%; OR 3.37, 95% CI 1.40-8.10) in women with recurrent miscarriage.
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