What question did this study set out to answer?

To investigate the correspondence between esophageal and regional pericardial pressures and evaluate how respiratory maneuvers influence left ventricular volume and configuration.

January 1, 1989Journal of Applied Physiology

Intrathoracic pressures and left ventricular configuration with respiratory maneuvers

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To investigate the correspondence between esophageal and regional pericardial pressures and evaluate how respiratory maneuvers influence left ventricular volume and configuration.
Evaluated esophageal and pericardial pressures across anterior, lateral, and inferior left ventricular surfaces in 12 dogs during beating and arrested heart states.
Applied intrathoracic pressure variations using spontaneous inspiration, Mueller maneuvers, phrenic nerve stimulation, intermittent positive pressure ventilation, and positive end-expiratory pressure.
Measured external left ventricular dimensions and volume changes across respiratory interventions in an additional 6 dogs.
Esophageal and pericardial pressure changes were equal in beating hearts, but anterior pericardial pressure increases were lower than esophageal pressure in high-volume arrested hearts.
In beating hearts, septal-lateral dimension and left ventricular volume decreased by approximately 3% (P < 0.05) during spontaneous inspiration, Mueller maneuvers, phrenic stimulation, and positive end-expiratory pressure.
In arrested hearts, left ventricular dimensions and volume decreased solely during positive end-expiratory pressure.

Structured PICO

Population

18 dogs (12 for pressure measurements, 6 for left ventricular configuration and volume measurements)

Intervention

Respiratory maneuvers including spontaneous inspiration, Mueller maneuver, phrenic stimulation, intermittent positive pressure ventilation (IPPV), and positive end-expiratory pressure (PEEP) in beating and arrested hearts

Outcome

Correspondence between esophageal (Pes) and pericardial pressures over the anterior, lateral, and inferior left ventricular (LV) surfaces, and external LV configuration and volumesurrogate

The relationship between esophageal and pericardial pressures is complex and depends on LV volume and local compliance, indicating that different forces account for LV volume changes during various respiratory maneuvers.

Discussion

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Implication

Respiratory effects on LV volume merit attention in hemodynamic models; extends animal data on cardiopulmonary interactions but leaves human translation open.

Cite This Study

Scharf et al. (1989) studied this question.

synapsesocial.com/papers/6a10e4ead06b5b96589fbdb6 https://doi.org/10.1152/jappl.1989.66.1.481

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Implication

Respiratory effects on LV volume merit attention in hemodynamic models; extends animal data on cardiopulmonary interactions but leaves human translation open.

Intrathoracic pressures and left ventricular configuration with respiratory maneuvers

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Intrathoracic pressures and left ventricular configuration with respiratory maneuvers

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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