Key result
High baseline von Willebrand factor linked to ~83% higher coronary heart disease risk.
Why the study?
The prospective relationship between circulating von Willebrand factor concentrations and risk of coronary heart disease in the general population was uncertain.
Do elevated circulating von Willebrand factor concentrations increase the risk of incident coronary heart disease in men?
Population
5661 men aged 40-59 years from 18 British towns
Comparison
Men in top third vs bottom third of baseline von Willebrand factor values
Design
Nested case-control study within a prospective cohort with meta-analysis
Follow-up
16 years
Authors
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Elevated von Willebrand factor may mark higher coronary risk; leaves open causality and whether measurement should guide prevention.
Case-Control (n=1,891)
Yes
Do elevated circulating von Willebrand factor concentrations increase the risk of incident coronary heart disease in men?
Odds Ratio: 1.83 (95% CI 1.43–2.35)
p-value: p=<0.0001
Elevated circulating von Willebrand factor concentrations are prospectively associated with an increased risk of incident coronary heart disease.
Peter H. Whincup (2002) conducted a case-control in coronary heart disease (n=1,891). High baseline von Willebrand factor concentrations (>126 IU/dL) vs. Low baseline von Willebrand factor concentrations (<90 IU/dL) was evaluated on coronary heart disease (OR 1.83, 95% CI 1.43-2.35, p=<0.0001). High baseline von Willebrand factor concentrations (>126 IU/dL) were associated with an increased risk of coronary heart disease compared to low concentrations (OR 1.83; 95% CI 1.43-2.35; P<0.0001).
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