Key result
Pericardiectomy significantly improved exercise capacity (VO2 peak 18.7 to 25.2 mL/kg/min) and sleep quality, but had no effect on sleep-disordered breathing in chronic constrictive pericarditis.
Why the study?
Heart failure is linked to exercise intolerance and sleep-disordered breathing, but studies evaluating these in patients with chronic constrictive pericarditis are scarce.
Does pericardiectomy improve exercise capacity and sleep in patients with symptomatic chronic constrictive pericarditis?
Population
25 consecutive patients with symptomatic chronic constrictive pericarditis scheduled for pericardiectomy
Comparison
Six months after pericardiectomy vs immediately before pericardiectomy
Design
Prospective observational cohort study
Follow-up
Six months
Authors
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Pericardiectomy was associated with improved exercise capacity and sleep quality in constrictive pericarditis; leaves open effects on sleep-disordered breathing and requires randomized confirmation.
Cohort (n=25)
No
Does pericardiectomy improve exercise capacity and sleep in patients with symptomatic chronic constrictive pericarditis?
Absolute Event Rate: 25.2% vs 18.7%
p-value: p=<0.001
Pericardiectomy in patients with symptomatic chronic constrictive pericarditis significantly improves exercise capacity and sleep quality, but does not significantly alter sleep-disordered breathing.
Melo et al. (2019) conducted a cohort in Chronic constrictive pericarditis (n=25). Pericardiectomy vs. Preoperative baseline was evaluated on VO2 peak (mL/kg/min) (p=<0.001). Pericardiectomy significantly improved exercise capacity (VO2 peak 18.7 to 25.2 mL/kg/min) and sleep quality, but had no effect on sleep-disordered breathing in chronic constrictive pericarditis.
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