Key result
Combined hypoxia and hypercapnia synergistically increased mean and low lung volume muscle sympathetic nerve activity (P<0.01), an effect that was overridden by high lung volume.
RCT (n=11)
Random order
p-value: p=<0.01
Hypoxia and hypercapnia interact synergistically to increase sympathetic nerve activity, an effect that is significantly overridden by lung inflation.
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Lung volume merits consideration when assessing sympathetic responses to hypoxia-hypercapnia; leaves open clinical translation in cardiorespiratory disease.
Jouett et al. (2015) conducted an RCT in Healthy subjects (n=11). Hypoxic and hypercapnic gas mixtures vs. Normoxic and normocapnic gas mixtures was evaluated on Changes in muscle sympathetic nerve activity (MSNA) (p=<0.01). Combined hypoxia and hypercapnia synergistically increased mean and low lung volume muscle sympathetic nerve activity (P<0.01), an effect that was overridden by high lung volume.
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