Key result
Intravenous immunoglobulin therapy for Guillain-Barré syndrome complicated by Takotsubo cardiomyopathy improved left ventricular ejection fraction from 30% and resolved wall motion abnormalities.
Case Report (n=1)
Takotsubo cardiomyopathy is a rare but reversible complication of Guillain-Barré syndrome that can improve following treatment of the underlying neurological condition.
Answers are grounded in this paper and cite their sources.
Case report of LVEF recovery with IVIG in GBS-Takotsubo is hypothesis-generating; should not change practice.
A 70-year-old woman presented with progressive lower extremity weakness and heaviness accompanied with chest pain. Troponin T was elevated, and an echocardiogram showed a left ventricular ejection fraction of 30% and a hypokinetic left ventricular apex. Neurophysiologic testing was consistent with Guillain-Barré syndrome, which was treated with intravenous immunoglobulin therapy. Repeat echocardiogram showed an improved left ventricular ejection fraction and no left ventricular wall motion abnormalities. Takotsubo cardiomyopathy is a rare complication of Guillain-Barré syndrome; less than 10 cases have been reported.
No takes yet. Share an insight, caveat, or question.
Gill et al. (2017) conducted a case report in Takotsubo cardiomyopathy with Guillain-Barré syndrome (n=1). Intravenous immunoglobulin therapy was evaluated. Intravenous immunoglobulin therapy for Guillain-Barré syndrome complicated by Takotsubo cardiomyopathy improved left ventricular ejection fraction from 30% and resolved wall motion abnormalities.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: