Key result
Depression and CVD share a bidirectional link potentially driven by inflammation and elevated hs-CRP.
Why the study?
Although comorbidity and a bidirectional relationship between CVD and depression have been observed, the underlying common mechanisms remain unclear.
This review highlights the bidirectional relationship between cardiovascular disease and depression, emphasizing the potential shared mechanism of inflammation.
May support integrated depression screening in CVD care; leaves open inflammation's causal role for prospective trials.
The comorbidity between cardiovascular disease (CVD) and depression has been observed for many years. Several biological and behavioral hypotheses have been proposed to explain this comorbidity. However, the underlying common mechanisms are still unclear. Evidence suggests a bidirectional relationship between depression and CVD. Inflammation has been implicated in the etiology of both depression and CVD. In this review, we aim to increase awareness for CVD and depression comorbidity and provide some insights about the possible role of inflammation.
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Baysak et al. (2020) conducted a review in Depression and Cardiovascular Disease. Evidence suggests a bidirectional relationship between depression and cardiovascular disease, with inflammation and elevated hs-CRP playing a possible underlying role in this comorbidity.
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