Key result
HIV-positive adults with major depressive disorder had a significantly higher risk of incident heart failure compared with HIV-negative adults without depression (adjusted HR 1.68; 95% CI 1.45-1.95).
Why the study?
Do HIV infection and major depressive disorder increase the risk of incident heart failure in veterans free from cardiovascular disease?
Population
81,427 Veterans Aging Cohort Study participants free from cardiovascular disease at baseline
Comparison
HIV infection and/or Major Depressive Disorder vs HIV- without MDD (reference group)
Design
Cohort
Follow-up
5.8 years
Authors
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MDD may add HF risk in HIV; extends prior associations but remains hypothesis-generating without trials.
Cohort (n=81,427)
Do HIV infection and major depressive disorder increase the risk of incident heart failure in veterans free from cardiovascular disease?
Effect estimate: adjusted HR 1.68 (95% CI 1.45-1.95)
Major depressive disorder is an independent risk factor for incident heart failure in adults with HIV, highlighting the importance of identifying and managing MDD in this population.
White et al. (2015) conducted a cohort in HIV and major depressive disorder (n=81,427). HIV+ with MDD vs. HIV- without MDD was evaluated on Incident heart failure (adjusted HR 1.68, 95% CI 1.45-1.95). HIV-positive adults with major depressive disorder had a significantly higher risk of incident heart failure compared with HIV-negative adults without depression (adjusted HR 1.68; 95% CI 1.45-1.95).
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