Key result
ATP2B1 gene variants linked to ~19% higher risk of hypertension.
Why the study?
The study was conducted to evaluate the relationships between ATP2B1 gene polymorphisms with blood pressure level and susceptibility to hypertension.
Are ATP2B1 gene polymorphisms rs2681472 and rs17249754 associated with susceptibility to hypertension and increased blood pressure levels?
Meta-Analysis (n=157,359)
Are ATP2B1 gene polymorphisms rs2681472 and rs17249754 associated with susceptibility to hypertension and increased blood pressure levels?
ATP2B1 gene polymorphisms rs2681472 and rs17249754 are significantly associated with increased blood pressure levels and higher susceptibility to hypertension.
Supports ATP2B1 variants in hypertension risk models; leaves open whether genotyping improves outcomes or guides therapy.
OBJECTIVE: The present study aimed to conduct a systematic review and meta-analysis to evaluate the relationships between ATP2B1 gene polymorphisms with blood pressure (BP) level and susceptibility to hypertension. METHODS: PubMed, Web of Science, Embase and China National Knowledge Infrastructure (CNKI) Databases were systematically searched by 2 independent researchers to screen studies on ATP2B1 gene polymorphisms and BP related phenotypes. The records retrieval period was limited from the formation of the database to March 4, 2021. Pooled odds rations (ORs) or β and their 95% confidence intervals (95%CI) were calculated to assess the association between ATP2B1 gene polymorphisms and the risk of hypertension or BP levels. Publication bias and sensitivity analysis were conducted to find potential bias. All the statistical analysis were conducted with Stata version 11.0 software. RESULTS: A total of 15 articles were ultimately included in the present study, including 15 polymorphisms of ATP2B1 gene. Nine articles (N = 65,362) reported the polymorphism rs17249754, and 7 articles(N = 91,997) reported rs2681472 (both loci were reported in 1 article). Meta-analysis showed that rs17249754 (G/A) and rs2681472 (A/G) were associated with the susceptibility to hypertension (rs17249754: OR = 1.19, 95%CI: 1.10-1.28; rs2681472: OR = 1.15, 95%CI: 1.12-1.17), and were positively associated with systolic BP (SBP) and diastolic blood pressure (DBP) (rs17249754: SBP, β=1.01, 95%CI: 0.86-1.16, DBP, β=0.48, 95%CI: 0.30-0.66; rs2681472: SBP, β=0.92, 95%CI: 0.77-1.07, DBP, β=0.50, 95%CI: 0.42-0.58) in the additive genetic model. Subgroup analysis stratified by race, population, sample size, and BP measurement method revealed that the association between A allele in rs2681472 polymorphism and risk of hypertension was slightly stronger in European (EUR) populations (OR = 1.16, 95%CI: 1.13-1.20) than in East Asians (OR = 1.14, 95%CI: 1.10-1.17). While in East Asians, relation between rs17249754 with risk of hypertension (OR = 1.19, 95%CI: 1.10-1.28) is stronger than rs2681472 (OR = 1.14, 95%CI: 1.10-1.17). CONCLUSIONS: Our study demonstrated that ATP2B1 gene polymorphism rs2681472 and rs17249754 were associated with BP levels and the susceptibility to hypertension.
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Xie et al. (2021) conducted a meta-analysis in Hypertension (n=157,359). ATP2B1 gene polymorphism rs17249754 (G allele) vs. Non-carriers (A allele) was evaluated on Susceptibility to hypertension (OR 1.19, 95% CI 1.10-1.28, p=<0.001). The ATP2B1 gene polymorphisms rs17249754 (G allele) and rs2681472 (A allele) were significantly associated with increased susceptibility to hypertension (OR 1.19 and OR 1.15, respectively).
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