Key result
The ATP2B1 rs12817819 A allele was associated with an increased risk for resistant hypertension in hypertensive patients with CAD (OR 1.65; 95% CI 1.36-1.95; P=1.60×10^-6).
Why the study?
Is the ATP2B1 rs12817819 A allele associated with an increased risk of resistant hypertension in hypertensive patients with CAD or suspected ischemic heart disease?
Population
1,982 hypertensive participants with documented coronary artery disease or suspected ischemic heart disease…
Comparison
ATP2B1 rs12817819 A allele (genetic polymorphism) vs Non-A allele genotypes
Design
Cohort
Authors
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Genetic variants tied to RHTN in CAD may aid risk stratification; leaves open replication and functional validation before any clinical use.
Cohort (n=1,982)
Yes
Is the ATP2B1 rs12817819 A allele associated with an increased risk of resistant hypertension in hypertensive patients with CAD or suspected ischemic heart disease?
Odds Ratio: 1.65 (95% CI 1.36–1.95)
p-value: p=1.60×10(-6)
The ATP2B1 rs12817819 A allele is a genetic variant associated with an increased risk of resistant hypertension in patients with coronary artery disease.
Fontana et al. (2014) conducted a cohort in Resistant hypertension (n=1,982). ATP2B1 rs12817819 A allele vs. Non-carriers / other genotypes was evaluated on Resistant hypertension (BP≥140/90 on 3 drugs, or any BP on ≥4 drugs) (OR 1.65, 95% CI 1.36 to 1.95, p=1.60×10(-6)). The ATP2B1 rs12817819 A allele was associated with an increased risk for resistant hypertension in hypertensive patients with CAD (OR 1.65; 95% CI 1.36-1.95; P=1.60×10^-6).
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