Key result
Recent advances map the genetic basis of AFib via linkage, GWAS, and rare coding variation.
Why the study?
Atrial fibrillation is a complex arrhythmia with genetic and environmental factors, and rapid progress in defining its genetic basis warrants outlining current knowledge gaps and future research directions.
This review summarizes the primary types of genetic analyses performed for atrial fibrillation and highlights existing knowledge gaps and future directions.
Answers are grounded in this paper and cite their sources.
AF genetic advances remain preclinical; leaves open functional validation and integration into risk stratification or therapy.
Atrial fibrillation is a common heart rhythm disorder that leads to an increased risk for stroke and heart failure. Atrial fibrillation is a complex disease with both environmental and genetic risk factors that contribute to the arrhythmia. Over the last decade, rapid progress has been made in identifying the genetic basis for this common condition. In this review, we provide an overview of the primary types of genetic analyses performed for atrial fibrillation, including linkage studies, genome-wide association studies, and studies of rare coding variation. With these results in mind, we aim to highlighting the existing knowledge gaps and future directions for atrial fibrillation genetics research.
No takes yet. Share an insight, caveat, or question.
Roselli et al. (2020) conducted a review in Atrial fibrillation. Recent progress in atrial fibrillation genetics has identified the genetic basis of the disease through linkage studies, genome-wide association studies, and studies of rare coding variation.
Synapse has enriched 10 related papers. Consider them for comparative context: