Key result
Early cardiac metabolic changes in prediabetes are linked to diastolic dysfunction preceding heart failure.
Why the study?
Diastolic dysfunction precedes heart failure and occurs in prediabetes linked to altered cardiac metabolism, but the exact etiology remains unknown.
Design
Narrative review
Authors
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Supports metabolic-diastolic link hypothesis in prediabetes; leaves open causal confirmation and therapeutic trials.
Understanding the relationship between altered cardiac metabolism and mitochondrial function in prediabetes may provide insights into the etiology of early diastolic dysfunction.
Wit‐Verheggen et al. (2021) conducted a review in Prediabetes. Early cardiac changes in fatty acid and glucose metabolism in prediabetes are closely linked to diastolic dysfunction, preceding the onset of cardiac failure.
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